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Objectives . To investigate the effect of 8 weeks of NMES + Ex (neuromuscular electrical stimulation combined with exercises) on pain and functional improvement in patients with knee osteoarthritis (OA) compared to exercise (Ex) alone.  Design . Randomized controlled trial.  Setting . A specialty outpatient clinic.  Participants . Patients ( N  = 100; women = 86, men = 14; age range, 50–75 years) with knee OA.  Interventions . Participants were randomly assigned to NMES + Ex or Ex group.  Outcome Measures . Numerical Rating Scale 0 to 10 (NRS) and the Timed Up and Go (TUG) test were the primary outcomes. The secondary outcomes used were the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).  Results . Following the interventions, a statistically significant improvement in both groups was observed in all outcomes assessed. For the comparison between the groups, no statistically significant difference was found between the NMES + Ex and the Ex groups in NRS ( P  = 0.52), TUG test ( P  = 0.12), and aspects of WOMAC: pain ( P  = 0.26), function ( P  = 0.23), and stiffness ( P  = 0.63).  Conclusion . The addition of NMES to exercise did not improve the outcomes assessed in knee OA patients. This study was registered at the Australian Clinical Trials Registry ( ACTRN012607000357459 ).

biomed research international

Effects of Neuromuscular Electrical Stimulation Combined with Exercises versus an Exercise Program on the Pain and the Function in Patients with Knee Osteoarthritis: A Randomized Controlled Trial