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In search of potential therapeutics for cancer, we described herein the synthesis, characterization, and  in vitro  anticancer activity of a novel series of curcumin analogues. The anticancer effects were evaluated on a panel of 60 cell lines, according to the National Cancer Institute (NCI) screening protocol. There were 10 tested compounds among 14 synthesized compounds, which showed potent anticancer activity in both one-dose and 5-dose assays. The most active compound of the series was 3,5-bis(4-hydroxy-3-methylstyryl)-1 H -pyrazole-1-yl(phenyl)methanone ( 10 ) which showed mean growth percent of −28.71 in one-dose assay and GI 50  values between 0.0079 and 1.86  µ M in 5-dose assay.

biomed research international

Synthesis, Characterisation, and<i>In Vitro</i>Anticancer Activity of Curcumin Analogues Bearing Pyrazole/Pyrimidine Ring Targeting EGFR Tyrosine Kinase

Synthesis, Characterisation, andIn VitroAnticancer Activity of Curcumin Analogues Bearing Pyrazole/Pyrimidine Ring Targeting EGFR Tyrosine Kinase