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Supercritical fluid carbon dioxide extraction technology was developed to gain the active components from a Taiwan native plant,  Zingiber officinale  (ginger). We studied the biological effects of ginger extracts via multiple assays and demonstrated the biofunctions in each platform. Investigations of ginger extracts indicated antioxidative properties in dose-dependant manners on radical scavenging activities, reducing powers and metal chelating powers. We found that ginger extracts processed moderate scavenging values, middle metal chelating levels, and slight ferric reducing powers. The antibacterial susceptibility of ginger extracts on  Staphylococcus aureus ,  Streptococcus sobrinus ,  S. mutans , and  Escherichia coli  was determined with the broth microdilution method technique. The ginger extracts had operative antimicroorganism potentials against both Gram-positive and Gram-negative bacteria. We further discovered the strong inhibitions of ginger extracts on lethal carcinogenic melanoma through  in vivo  xenograft model. To sum up, the data confirmed the possible applications as medical cosmetology agents, pharmaceutical antibiotics, and food supplements.

the scientific world journal/thescientificworldjournal

Functional Ginger Extracts from Supercritical Fluid Carbon Dioxide Extraction via<i>In Vitro</i>and<i>In Vivo</i>Assays: Antioxidation, Antimicroorganism, and Mice Xenografts Models

Functional Ginger Extracts from Supercritical Fluid Carbon Dioxide Extraction viaIn VitroandIn VivoAssays: Antioxidation, Antimicroorganism, and Mice Xenografts Models