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Ethambutol (EMB) continues to be used as part of a standard drug regimen for the treatment of tuberculosis (TB). Mutations in the  embB  gene and those within its conserved EMB resistance determining region (ERDR) in particular have repeatedly been associated with resistance to EMB in  Mycobacterium tuberculosis . The aim of this study was to examine the mutational “hot spots” in the  embB  gene, including the ERDR, among multidrug-resistant (MDR)  M. tuberculosis  clinical isolates and to find a possible association between  embB  mutations and resistance to EMB. An 863-bp fragment of the  embB  gene was sequenced in 17 EMB-resistant and 33 EMB-susceptible MDR-TB isolates. In total, eight  embB  mutation types were detected in 6 distinct codons of 27 (54%)  M. tuberculosis  isolates. Mutations in codon 306 were most common, found in both EMB-resistant (9) and EMB-susceptible (11) isolates. Only mutations in codons 406 and 507 were found exclusively in four and one EMB-resistant isolates, respectively. Sequence analysis of the ERDR in the  embB  gene is not sufficient for rapid detection of EMB resistance, and the codon 306 mutations are not good predictive markers of resistance to EMB.

biomed research international

Mutations in the<i>embB</i>Gene and Their Association with Ethambutol Resistance in Multidrug-Resistant<i>Mycobacterium tuberculosis</i>Clinical Isolates from Poland

Mutations in theembBGene and Their Association with Ethambutol Resistance in Multidrug-ResistantMycobacterium tuberculosisClinical Isolates from Poland