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Despite recent advances in therapeutic and diagnostic approaches, coronary artery disease (CAD) and its related cardiac disorders represent the most common cause of death in the United States. Nuclear myocardial perfusion imaging (MPI) technologies play a pivotal role in the diagnosis and treatment design for CAD. Recently, in order to develop improved MPI agents for diagnosis of CAD,  99m Tc-[bis(dimethoxypropylphosphinoethyl)-ethoxyethyl-amine(PNP5)]-[bis(N-ethoxyethyl)dithiocarbamato(DBODC)]nitride(N-DBODC5)( 99m Tc-N-DBODC5) with a faster liver clearance than conventional single-photon emission computed tomography (SPECT) imaging agents (technetium 99m sestamibi ( 99m Tc-MIBI) or technetium 99m tetrofosmin) has been introduced. In preclinical and phase I studies,  99m Tc-N-DBODC5 has shown characteristics of an essentially ideal MPI tracer. Importantly, however, there is no data to support the use of  99m Tc-N-DBODC5 to evaluate myocardial ischemia in patients with suspected CAD. The present study was designed to assess the clinical value of this agent; the findings of stress and rest MPI after the administration of this agent were compared to those of stress and rest  99m Tc-MIBI, as well as those of coronary angiography, with respect to the detection of CAD. Our findings indicated the usefulness of  99m Tc-N-DBODC5 as a promising MPI agent.

Comparison of99mTc-N-DBODC5 and99mTc-MIBI of Myocardial Perfusion Imaging for Diagnosis of Coronary Artery Disease

Comparison of^99mTc-N-DBODC5 and^99mTc-MIBI of Myocardial Perfusion Imaging for Diagnosis of Coronary Artery Disease