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Objective .  Artemisia ciniformis  (Asteraceae) and  A. biennis  are two of 34  Artemisia  species growing naturally in Iran. In this study we investigated whether different extracts of  A. ciniformis  and  A. biennis  have protective effect against hydrogen peroxide-induced cytotoxicity in rat cardiomyoblast cells (H9c2).  Method . The dried and ground aerial parts of these two species were extracted successively using petroleum ether (40–60), dichloromethane, ethyl acetate (EA), ethanol (EtOH) and ethanol : water (1 : 1) by maceration method. To evaluate whether different extracts of  A. ciniformis  and  A. biennis  protect cardiomyoblast H9c2 cells from H 2 O 2  cytotoxicity, we examined the direct cytotoxic effect of H 2 O 2  on H9c2 cells in the presence and absence of different extracts. After then, cell viability was measured by MTT assay.  Results . H 2 O 2  induced cytotoxicity in a concentration dependent manner. The IC 50  value was 62.5   μ  M for 24 h exposure. However, pretreatment of cells with various concentrations of EA, EtOH, and EtOH/wt extract of  A. ciniformis  protected cells from H 2 O 2 -induced cytotoxicity. Moreover, pretreatment with EA, EtOH and EtOH/wt extracts of  A. ciniformis  lead to a decrease in the reactive oxygen species (ROS) generation. Taken together our observation indicated that nontoxic concentration of different extracts of  A. ciniformis  has protective effect on H 2 O 2 -induced cytotoxicity in H9c2 cells.

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Extracts of<i>Artemisia ciniformis</i>Protect Cytotoxicity Induced by Hydrogen Peroxide in H9c2 Cardiac Muscle Cells through the Inhibition of Reactive Oxygen Species

Extracts ofArtemisia ciniformisProtect Cytotoxicity Induced by Hydrogen Peroxide in H9c2 Cardiac Muscle Cells through the Inhibition of Reactive Oxygen Species