English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Secretory phospholipases A 2  (sPLA 2 ) exert proinflammatory actions through lipid mediators. These enzymes have been found to be elevated in many inflammatory disorders such as rheumatoid arthritis, sepsis, and atherosclerosis. The aim of this study was to evaluate the effect of harpalycin 2 (Har2), an isoflavone isolated from  Harpalyce brasiliana  Benth., in the enzymatic, edematogenic, and myotoxic activities of sPLA 2  from  Bothrops pirajai, Crotalus durissus terrificus, Apis mellifera,  and  Naja naja  venoms. Har2 inhibits all sPLA 2  tested. PrTX-III ( B. pirajai  venom) was inhibited at about 58.7%, Cdt F15 ( C. d. terrificus  venom) at 78.8%, Apis (from bee venom) at 87.7%, and Naja ( N. naja  venom) at 88.1%. Edema induced by exogenous sPLA 2  administration performed in mice paws showed significant inhibition by Har2 at the initial step. In addition, Har2 also inhibited the myotoxic activity of these sPLA 2 s. In order to understand how Har2 interacts with these enzymes, docking calculations were made, indicating that the residues His48 and Asp49 in the active site of these enzymes interacted powerfully with Har2 through hydrogen bonds. These data pointed to a possible anti-inflammatory activity of Har2 through sPLA 2  inhibition.

evidence-based complementary and alternative medicine

Inhibition of Neurotoxic Secretory Phospholipases A<sub>2</sub>Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from<i>Harpalyce brasiliana</i>Benth

Inhibition of Neurotoxic Secretory Phospholipases A2Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated fromHarpalyce brasilianaBenth

Inhibition of Neurotoxic Secretory Phospholipases A₂Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated fromHarpalyce brasilianaBenth