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Chinese herbal medicinal (CHM) extracts from fourteen plants were investigated in cell-based  in vitro  assays for their effect on nuclear factor   κ  B (NF-  κ  B), a key regulator of inflammation, as well as on peroxisome proliferator-activated receptors (PPARs) being key regulators of genes involved in lipid and glucose metabolism. 43% of the investigated CHMs showed NF-  κ  B inhibitory and 50% PPAR  α   and PPAR  γ   activating effects. Apolar extracts from cortex and flos of  Albizia julibrissin  Durazz. and processed rhizomes of  Arisaema  sp. and  Pinellia ternata  (Thunb.) Breit. that effectively inhibited TNF-  α  -induced NF-  κ  B activation and dose-dependently activated PPAR  α   and PPAR  γ   were further investigated. Bioassay-guided fractionation and analysis by GC-MS led to the identification of fatty acids as PPAR agonists, including linoleic and palmitic acid.

Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARαand PPARγand the Respective Bioactive Compounds