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Salvianolic acid B (SA-B) is water-soluble component of  Radix Salvia miltiorrhiza . The previous work indicated that SA-B can inhibit MAPK and Smad signaling in activated hepatic stellate cells (HSCs) to perform anti-fibrotic activity Lv et al. 2010. However, some studies have shown that there is cross-talk between MAPK and Smad in certain cell types. Thus, the anti-fibrotic action of SA-B may be through the cross-talk. In order to clarify the mechanism of SA-B further, we knocked down Smad in LX-2 cells (SRV4) via RNAi, and then added TGF-  β  1, and PD98059 or SB203580 and SA-B. The levels of p-MEK and p-p38 were inhibited by SA-B in SRV4 independent of TGF-  β  1. The expression of Col I and   α  -SMA in SRV4 could be reduced by SA-B independent TGF-  β  1. SB203580 had not significant effect on p-MEK in SRV4 stimulated by TGF-  β  1. The levels of p-MEK in SRV4 were not increased significantly after TGF-  β  1 stimulation. PD98059 had no effect on the levels of p-p38 in SRV4 irrespective of TGF-  β  1. In conclusion, SA-B inhibits the synthesis of Col I in LX-2 cells independent of TGF-  β  1 stimulation, and the anti-fibrotic effect of SA-B is due to direct inhibition of p38 signaling and inhibition the cross-talk of Smad to ERK signaling.

evidence-based complementary and alternative medicine

Salvianolic Acid B Inhibits ERK and p38 MAPK Signaling in TGF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi mathvariant="bold">β</mml:mi></mml:math>1-Stimulated Human Hepatic Stellate Cell Line (LX-2) via Distinct Pathways

Salvianolic Acid B Inhibits ERK and p38 MAPK Signaling in TGF-β1-Stimulated Human Hepatic Stellate Cell Line (LX-2) via Distinct Pathways