English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The objective of this study is to evaluate the lowering of uric acid using  Balanophora laxiflora  extracts and derived phytochemicals on potassium-oxonate-(PO-) induced hyperuricemia in mice. The results revealed that ethyl acetate (EtOAc) fraction of  B. laxiflora  extracts exhibited strong xanthine-oxidase-(XOD-) inhibitory activity. In addition, among the 10 subfractions (EA1–10) derived from EtOAc fraction, subfraction 8 (EA8) exhibited the best XOD-inhibitory activity. Four specific phytochemicals, 1- O -( E )-caffeoyl-  β  - D -glucopyranose ( 1 ), 1- O -( E )- p -coumaroyl-  β  - D -glucopyranose ( 2 ), 1,3-di- O -galloyl-4,6-( S )-hexahydroxydiphenoyl-  β  - D -glucopyranose ( 3 ), and 1- O -( E )-caffeoyl-4,6-( S )-hexahydroxydiphenoyl-  β  - D -glucopyranose ( 4 ), were further isolated and identified from this subfraction. Compounds  3  and  4  exhibited the strongest XOD-inhibitory activity compared with other compounds, and both hydrolyzable tannins were determined to be noncompetitive inhibitors according to the Lineweaver-Burk plot. On the other hand, the  in vivo  hypouricemic effect in hyperuricemic mice was consistent with XOD-inhibitory activity, indicating that  B. laxiflora  extracts and derived phytochemicals could be potential candidates as new hypouricemic agents.

The Hypouricemic Effect ofBalanophora laxifloraExtracts and Derived Phytochemicals in Hyperuricemic Mice