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LYR motif containing 1 ( LYRM1 ) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor-  α   (TNF-  α  ) are shown to upregulate  LYRM1  mRNA expression in 3T3-L1 adipocytes. Conversely, resistin and rosiglitazone exert an inhibitory effect on  LYRM1  mRNA expression. These results suggest that the expression of  LYRM1  mRNA is affected by a variety of factors that are related to insulin sensitivity.  LYRM1  may be an important mediator in the development of obesity-related insulin resistance.

Regulation ofLYRM1Gene Expression by Free Fatty Acids, Adipokines, and Rosiglitazone in 3T3-L1 Adipocytes