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Euclea natalensis  A.DC.,  Knowltonia vesicatoria  (L.f) Sims, and  Pelargonium sidoides  DC. are South African plants traditionally used to treat tuberculosis. Extracts from these plants were used in combination with isoniazid (INH) to investigate the possibility of synergy with respect to antimycobacterial activity. The ethanol extract of  K. vesicatoria  was subjected to fractionation to identify the active compounds. The activity of the  Knowltonia  extract remained superior to the fractions with a minimum inhibitory concentration (MIC) of 625.0   μ  g/mL against  Mycobacterium smegmatis  and an MIC of 50.00   μ  g/mL against  M. tuberculosis . The  K. vesicatoria  extract was tested against two different drug-resistant strains of  M. tuberculosis , which resulted in an MIC of 50.00   μ  g/mL on both strains. The combination of  K. vesicatoria  with INH exhibited the best synergistic antimycobacterial activity with a fractional inhibitory concentration index of 0.25 (a combined concentration of 6.28   μ  g/mL). A fifty percent inhibitory concentration of this combination against U937 cells was 121.0   μ  g/mL. Two compounds, stigmasta-5,23-dien-3-ol (1) and 5-(hydroxymethyl)furan-2(5H)-one (2), were isolated from  K. vesicatoria  as the first report of isolation for both compounds from this plant and the first report of antimycobacterial activity. Compound (1) was active against drug-sensitive  M. tuberculosis  with an MIC of 50.00   μ  g/mL.

Synergistic Antimycobacterial Actions ofKnowltonia vesicatoria(L.f) Sims