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Infant CD4 +  T-cell responses to bacterial infections or vaccines have been extensively studied, whereas studies on CD8 +  T-cell responses focused mainly on viral and intracellular parasite infections. Here we investigated CD8 +  T-cell responses upon  Bordetella pertussis  infection in infants, children, and adults and pertussis vaccination in infants. Filamentous hemagglutinin-specific IFN-  γ   secretion by circulating lymphocytes was blocked by anti-MHC-I or -MHC-II antibodies, suggesting that CD4 +  and CD8 +  T lymphocytes are involved in IFN-  γ   production. Flow cytometry analyses confirmed that both cell types synthesized antigen-specific IFN-  γ  , although CD4 +  lymphocytes were the major source of this cytokine. IFN-  γ   synthesis by CD8 +  cells was CD4 +  T cell dependent, as evidenced by selective depletion experiments. Furthermore, IFN-  γ   synthesis by CD4 +  cells was sometimes inhibited by CD8 +  lymphocytes, suggesting the presence of CD8 +  regulatory T cells. The role of this dual IFN-  γ   secretion by CD4 +  and CD8 +  T lymphocytes in pertussis remains to be investigated.

clinical and developmental immunology/clinical and developmental immunology

Both<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD4</mml:mtext></mml:mrow><mml:mo>+</mml:mo></mml:msup></mml:mrow></mml:math>and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msup><mml:mrow><mml:mtext>CD8</mml:mtext></mml:mrow><mml:mo>+</mml:mo></mml:msup></mml:mrow></mml:math>Lymphocytes Participate in the IFN-γ Response to Filamentous Hemagglutinin from<i>Bordetella pertussis</i>in Infants, Children, and Adults

BothCD4+andCD8+Lymphocytes Participate in the IFN-γ Response to Filamentous Hemagglutinin fromBordetella pertussisin Infants, Children, and Adults