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Background . Pentoxifylline (PTX) anti-TNF properties are known to exert hepatoprotective effects in various liver injury models. The aim of this study was to investigate whether PTX has beneficial roles in the development of methionine- and choline-deficient-(MCD-) diet-induced NAFLD SD rats  in vivo  and TNF-  α  -induced Hep3B cells  in vitro .  Methods . SD Rats were classified according to diet (chow or MCD diet) and treatment (normal saline or PTX injection) over a period of 4 weeks: group I (chow + saline,  n  = 4), group II (chow + PTX), group III (MCD + saline), and group IV (MCD + PTX). Hep3B cells were treated with 100 ng/ml TNF-  α   (24 h) in the absence or presence of PTX (1 mM).  Results . PTX attenuated MCD-diet-induced serum ALT levels and hepatic steatosis. In real-time PCR and western blotting analysis, PTX decreased MCD-diet-induced TNF-alpha mRNA expression and proapoptotic unfolded protein response by ER stress (GRP78, p-eIF2, ATF4, IRE1  α  , CHOP, and p-JNK activation)  in vivo . PTX (1 mM) reduced TNF-  α  -induced activation of GRP78, p-eIF2, ATF4, IRE1  α  , and CHOP  in vitro .  Conclusion . PTX has beneficial roles in the development of MCD-diet-induced steatohepatitis through partial suppression of TNF-  α   and ER stress.

experimental diabetes research

Pentoxifylline Attenuates Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis by Suppressing TNF-<b><i>α</i></b>Expression and Endoplasmic Reticulum Stress

Pentoxifylline Attenuates Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis by Suppressing TNF-αExpression and Endoplasmic Reticulum Stress