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Aim . Hyul-bu-chuke-tang (HCEt) is a well-known traditional herbal medicine that is used for the treatment of ischemic cerebrovascular disorders. We investigated the acute effects of HCEt on erythrocyte deformability and cerebrovascular CO 2  reactivity (CVR) in healthy male subjects.  Materials and Methods . We examined erythrocyte deformability in an HCEt group ( n  = 14) and a control group ( n  = 10). CVR was measured using hyperventilation-induced CO 2  reactivity of the middle cerebral artery and transcranial Doppler (TCD) in the HCEt group ( n  = 11). A historical control group ( n  = 10) of CVR measurements was also created from our previous study. All measurements were performed prior to and 1, 2, and 3 hours after HCEt administration.  Results . HCEt significantly improved erythrocyte deformability 1 hour after administration compared to the control group (2.9 ± 1.1% versus −0.6 ± 1.0%,  P  = 0.034). HCEt significantly improved the CVR 2 hours after administration compared to the historical control group (9.1 ± 4.0% versus −8.1 ± 4.1%,  P  = 0.007). The mean blood pressure and pulse rate did not vary from baseline values in either group.  Conclusions . We demonstrated that HCEt improved erythrocyte deformability and CVR. Our findings suggest that an improvement in erythrocyte deformability contributes to HCEt's effect on cerebral microcirculation.

Effects of Hyul-Bu-Chuke-Tang on Erythrocyte Deformability and Cerebrovascular CO2Reactivity in Normal Subjects

Effects of Hyul-Bu-Chuke-Tang on Erythrocyte Deformability and Cerebrovascular CO₂Reactivity in Normal Subjects