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. Posttraumatic stress disorder (PTSD) is accompanied by poor general psychological status (GPS). In the present study, we investigated the effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD.  Methods . A randomized, double-blind, placebo-controlled trial compared a Chinese herbal formula,  Xiao-Tan-Jie-Yu-Fang  (XTJYF), to placebo in 2008 Sichuan earthquake survivors with PTSD. Patients were randomized into XTJYF ( n  = 123) and placebo ( n  = 122) groups. Baseline-to-end-point score changes in the three global indices of the Symptom Checklist-90-Revised (SCL-90-R) and rates of response in the SCL global severity index (GSI) were the primary endpoints. A subanalysis of the nine SCL factors and the sleep quality score were secondary endpoints.  Results and Discussion . Compared to placebo, the XTJYF group was significantly improved in all three SCL global indices ( P  = 0.001~0.028). More patients in the XTJYF group reported “much improved” than the placebo group ( P  = 0.001). The XTJYF group performed significantly better than control in five out of nine SCL factors (somatization, obsessive-compulsive behavior, depression, anxiety, and hostility ( P  = 0.001~0.036)), and in sleep quality score ( P  < 0.001). XTJYF produced no serious adverse events. These findings suggest that XTJYF may be an effective and safe treatment option for improving GPS in patients with PTSD.

evidence-based complementary and alternative medicine

A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors