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Background . Patients seek an effective alternative to pharmacotherapy including herbal treatment options for allergic rhinitis and rhinosinusitis.  Material and Methods . Nasal mucosal tissue was obtained from 12 patients, fragmented, preincubated with tissue culture medium,  S. baicalensis  and/or  E. senticosus  and/or vitamin C (each compound 0.2   μ  g/mL and 2   μ  g/mL) for 1 hour at 37°C/5% CO2, and stimulated with anti-IgE for 30 minutes and 6 hours to imitate the allergic early and late phases. Furthermore, Staphylococcus aureus superantigen B (SEB) stimulation for 6 hours was used to imitate T-cell activation.  Results . The combination of  S. baicalensis  and  E. senticosus  had a more potent suppressive effect on the release of PGD2, histamine, and IL-5 than  S. baicalensis  alone. The combination also resulted in a significant inhibition of SEB-induced cytokines comparable or superior to an established topical corticosteroid, fluticasone propionate. Vitamin C increased ciliary beat frequency, but had no anti-inflammatory effects.  Discussion . The combination of  S. baicalensis  and  E. senticosus  may be able to significantly block allergic early-and late-phase mediators and substantially suppress the release of proinflammatory, and Th1-, Th2-, and Th17—derived cytokines.

evidence-based complementary and alternative medicine

A Herbal Composition of<i>Scutellaria baicalensis</i>and<i>Eleutherococcus senticosus</i>Shows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model

A Herbal Composition ofScutellaria baicalensisandEleutherococcus senticosusShows Potent Anti-Inflammatory Effects in an Ex Vivo Human Mucosal Tissue Model