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Oleifolioside A, a new triterpenoid compound isolated from  Dendropanax morbifera  Leveille ( D. morbifera ), was shown in this study to have potent inhibitory effects on lipopolysaccharide (LPS-)stimulated nitric oxide (NO) and prostaglandin E 2  (PGE 2 ) production in RAW 264.7 macrophages. Consistent with these findings, oleifolioside A was further shown to suppress the expression of LPS-stimulated inducible nitric oxide synthase (iNOS) and cyclooxigenase-2 (COX-2) in a dose-dependent manner at both the protein and mRNA levels and to significantly inhibit the DNA-binding activity and transcriptional activity of NF- κ B in response to LPS. These results were found to be associated with the inhibition of the degradation and phosphorylation of I κ B- α  and subsequent translocation of the NF- κ B p65 subunit to the nucleus. Inhibition of NF- κ B activation by oleifolioside A was also shown to be mediated through the prevention of p38 MAPK and ERK1/2 phosphorylation. Taken together, our results suggest that oleifolioside A has the potential to be a novel anti-inflammatory agent capable of targeting both the NF- κ B and MAPK signaling pathways.

evidence-based complementary and alternative medicine

Oleifolioside A, a New Active Compound, Attenuates LPS-Stimulated iNOS and COX-2 Expression through the Downregulation of NF-<i>κ</i>B and MAPK Activities in RAW 264.7 Macrophages

Oleifolioside A, a New Active Compound, Attenuates LPS-Stimulated iNOS and COX-2 Expression through the Downregulation of NF-κB and MAPK Activities in RAW 264.7 Macrophages