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Acetone extracts of selected plant species were evaluated for their  in vitro  cytotoxicity against a noncancerous African green monkey kidney (Vero) cell line and an adenocarcinoma cervical cancer (HeLa) cell line. The plants studied were  Origanum vulgare  L. (Oregano),  Rosmarinus officinalis  L. (Upright and ground cove rosemary),  Lavandula spica  L. (Lavender),  Laurus nobilis  L. (Bay leaf),  Thymus vulgaris  L. (Thyme),  Lavandula x intermedia  L. (Margaret Roberts Lavender),  Petroselinum crispum  Mill. (Curly leaved parsley),  Foeniculum vulgare  Mill. (Fennel), and  Capsicum annuum  L. (Paprika). Antioxidant activity was determined using a quantitative DPPH (1,1-diphenyl-2-picryl hydrazyl) assay. The rosemary species exhibited effective radical scavenging capacity with 50% inhibitory concentration (IC 50 ) of 3.48 ± 0.218  μ g/mL and 10.84 ± 0.125  μ g/mL and vitamin C equivalents of 0.351 g and 1.09 g for McConnell's Blue and Tuscan Blue, respectively. Cytotoxicity was measured using XTT (Sodium 3′-[1-(phenyl amino-carbonyl)-3,4-tetrazolium]-bis-[4-methoxy-6-nitro] benzene sulfonic acid hydrate) colorimetric assay. Only  L. nobilis  and  O. vulgare  exhibited pronounced effects on the HeLa cell line. Dose-dependent studies revealed IC 50  of 34.46 ± 0.48  μ g/mL and 126.3 ± 1.00  μ g/mL on the HeLa cells and on the Vero cells 124.1  μ g/mL ± 18.26 and 163.8  μ g/mL ± 2.95 for  L. nobilis  and  O. vulgare , respectively. Light (eosin and haematoxylin staining) and confocal microscopy (Hoechst 33342, acridine orange, and propidium iodide staining) were used to evaluate the cytotoxic mechanism of action for  L. nobilis  and  O. vulgare .

Anticancer Activity of Certain Herbs and Spices on the Cervical Epithelial Carcinoma (HeLa) Cell Line