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In patients on maintenance hemodialysis several factors reduce the body stored carnitine which could lead to dyslipidemia, anemia, and general health in these patients. We evaluated the effect of oral L-carnitine supplementation on lipid profiles, anemia, and quality of life (QOL) in hemodialysis patients. In a randomized, double-blinded, placebo-controlled trial, end-stage renal disease (ESRD) patients on hemodialysis received either L-carnitine 1 g/d ( n  = 24) or placebo (27 patients) for 16 weeks. At the end of the study, there was a significant decrease in triglyceride (−31.1 ± 38.7 mg/dL,  P  = 0.001) and a significant increase in HDL (3.7 ± 2.8 mg/dL,  P  < 0.001) levels in the carnitine group. Decrease in total cholesterol (−6.6 ± 16.0 mg/dL,  P  = 0.075) and increase in hemoglobin (0.7 ± 1.7 g/dL,  P  = 0.081) concentrations in the carnitine group were not significant. There was no statistically significant changes in LDL in any group ( P  > 0.05). Erythropoietin dose was significantly decreased in both the carnitine (−4750 ± 5772 mg,  P  = 0.001) and the placebo group (−2000 ± 4296 mg,  P  < 0.05). No improvement was observed in QOL scores of two groups. In ESRD patients under maintenance hemodialysis, oral L-carnitine supplementation may reduce triglyceride and cholesterol and increase HDL and hemoglobin and subsequently reduce needed erythropoietin dose without effect on QOL.

journal of nutrition and metabolism

Effects of Oral L-Carnitine Supplementation on Lipid Profile, Anemia, and Quality of Life in Chronic Renal Disease Patients under Hemodialysis: A Randomized, Double-Blinded, Placebo-Controlled Trial