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Recent studies suggested that  Eurycoma longifolia , a herbal plant, may have the potential to treat osteoporosis in elderly male. This study aimed to determine the effects of  Eurycoma longifolia  supplementation on the trabecular bone microarchitecture of orchidectomised rats (androgen-deficient osteoporosis model). Forty-eight-aged (10–12 months old)  Sprague Dawley  rats were divided into six groups of sham-operated (SHAM), orchidectomised control (ORX), orchidectomised + 7 mg/rat testosterone enanthate (TEN) and orchidectomised +  Eurycoma longifolia  30 mg/kg (EL30), orchidectomised +  Eurycoma longifolia  60 mg/kg (EL60), orchidectomised +  Eurycoma longifolia  90 mg/kg (EL90). Rats were euthanized following six weeks of treatment. The left femora were used to measure the trabecular bone microarchitecture using micro-CT. Orchidectomy significantly decreased connectivity density, trabecular bone volume, and trabecular number compared to the SHAM group. Testosterone replacement reversed all the orchidectomy-induced changes in the micro-CT parameters. EL at 30 and 60 mg/kg rat worsened the trabecular bone connectivity density and trabecular separation parameters of orchidectomised rats. EL at 90 mg/kg rat preserved the bone volume. High dose of EL (90 mg/kg) may have potential in preserving the bone microarchitecture of orchidectomised rats, but lower doses may further worsen the osteoporotic changes.

Bone Micro-CT Assessments in an Orchidectomised Rat Model Supplemented withEurycoma longifolia