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Bojesodok-eum  (BSE) is a herbal prescription consisting of  Coptidis Rhizoma  and  Scutellariae Radix  as main components. This paper investigated the effects of BSE on the induction of nitric oxide (NO), prostaglandin E 2  (PGE 2 ), and proinflammatory cytokines that are caused by lipopolysaccharide (LPS) in murine macrophage cell line and on the paw edema formation in animals. Administration of BSE (0.3 g/kg and 1 g/kg) in rats significantly inhibited carrageenan-induced paw edema formation, as did dexamethasone, an anti-inflammatory positive control drug. In cell model, treatment of BSE decreased the production of NO and PGE 2  in RAW264.7 cells stimulated by LPS. BSE also inhibited the expression of iNOS and COX-2 protein as well as COX activity in a concentration-dependent manner. Consistently, BSE suppressed the ability of LPS to produce TNF- α , interleukin-1 β , and interleukin-6. LPS treatment induced nuclear NF- κ B level and I- κ B α  phosphorylation, which were inhibited subsequent treatment of BSE, suggesting its repression of LPS-inducible NF- κ B activation. BSE abrogated the induction of NO, PGE 2 , and proinflammatory cytokines, as well as iNOS and COX-2 protein expression in RAW264.7 cells stimulated by LPS as mediated with NF- κ B inhibition.

evidence-based complementary and alternative medicine

<i>Bojesodok-eum</i>, a Herbal Prescription, Ameliorates Acute Inflammation in Association with the Inhibition of NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold-italic">κ</mml:mi></mml:mrow></mml:math>B-Mediated Nitric Oxide and ProInflammatory Cytokine Production

Bojesodok-eum, a Herbal Prescription, Ameliorates Acute Inflammation in Association with the Inhibition of NF-κB-Mediated Nitric Oxide and ProInflammatory Cytokine Production