English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The development of strains of herpes simplex virus (HSV) resistant to drugs has been reported among the immunocompromised patients. Thus, there is a need to develop new therapeutic agents for HSV infections. We evaluated the anti-HSV activity of  Bidens pilosa  ( B. pilosa ), a tropical weed, in tissue culture cells and a mouse model.  B. pilosa  extract showed potent virucidal activity. It inhibited plaque formation and suppressed virus yield in Vero and RAW 264.7 cells infected with HSV-1 and HSV-2. Both the binding of virus to host cells and penetration of virus into cells were also blocked by  B. pilosa . Furthermore,  B. pilosa  was effective against thymidine kinase-deficient and phosphonoacetate-resistant HSV-1 strains.  B. pilosa  treatment increased the survival rate of HSV-infected mice and limited the development of skin lesions. Our results indicate that  B. pilosa  has anti-HSV activity and is thus a potentially useful medical plant for treatment of HSV infection.

Efficacy ofBidens pilosaExtract against Herpes Simplex Virus InfectionIn VitroandIn Vivo