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Acute lung injury (ALI), instilled by lipopolysaccharide (LPS), is a severe illness with excessive mortality and has no specific treatment strategy. Luteolin is an anti-inflammatory flavonoid and widely distributed in the plants. Pretreatment with luteolin inhibited LPS-induced histological changes of ALI and lung tissue edema. In addition, LPS-induced inflammatory responses, including increased vascular permeability, tumor necrosis factor (TNF)-  α   and interleukin (IL)-6 production, and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), were also reduced by luteolin in a concentration-dependent manner. Furthermore, luteolin suppressed activation of NF  κ  B and its upstream molecular factor, Akt. These results suggest that the protection mechanism of luteolin is by inhibition of NF  κ  B activation possibly via Akt.

evidence-based complementary and alternative medicine

Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NF<b><i>κ</i></b>B Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice

Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice