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Background . Diabetes is associated with increased cardiovascular disease, but the underlying cellular and molecular mechanisms are poorly understood. One proposed mechanism is that diabetes aggravates atherosclerosis by enhancing plaque inflammation. The  Akita  mouse has recently been adopted as a relevant model for microvascular complications of diabetes. Here we investigate the development of atherosclerosis and inflammation in vessels of  Akita  mice on  LDLr   −/−  background.  Methods and Results .  Akita-LDLr   −/−  and  LDLr   −/−  mice were fed high-fat diet from 6 to 24 weeks of age. Blood glucose levels were higher in both male and female  Akita-LDLr   −/−  mice (137% and 70%, resp.). Male  Akita-LDLr   −/−  mice had markedly increased plasma cholesterol and triglyceride levels, a three-fold increase in atherosclerosis, and enhanced accumulation of macrophages and T-cells in plaques. In contrast, female  Akita-LDLr   −/−  mice demonstrated a modest 29% increase in plasma cholesterol and no significant increase in triglycerides, atherosclerosis, or inflammatory cells in lesions. Male  Akita-LDLr   −/−  mice had increased levels of plasma IL-1  β   compared to nondiabetic mice, whereas no such difference was seen between female diabetic and nondiabetic mice.  Conclusion .  Akita-LDLr   −/−  mice display considerable gender differences in the development of diabetic atherosclerosis. In addition, the increased atherosclerosis in male  Akita-LDLr   −/−  mice is associated with an increase in inflammatory cells in lesions.

Increased Inflammation in Atherosclerotic Lesions of DiabeticAkita-LDLr−/−Mice Compared to NondiabeticLDLr−/−Mice

Increased Inflammation in Atherosclerotic Lesions of DiabeticAkita-LDLr^−/−Mice Compared to NondiabeticLDLr^−/−Mice