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Objectives . This study evaluated IL-17 and IL-11 in gingival crevicular fluid (GCF) of generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP) patients in relation to periodontopathic bacteria.  Subjects and Methods . GCF samples were collected from 65 subjects including 25 CP, 25 GAgP, and 15 controls (C) and analyzed for IL-17 and IL-11 by an enzyme-linked immunosorbent assay. Molecular detection of bacteria in the dental plaque was determined by polymerase chain reaction.  Results . The total amount of IL-17 was significantly higher in GAgP group than in GCP and C groups ( P  < 0.001). The IL-11 concentration was significantly higher in C and GCP groups than GAgP group ( P  < 0.001). The IL-11/IL-17 ratio was significantly higher in the C group than in GCP and GAgP groups ( P  < 0.05). Moreover, GAgP group showed lower ratios of IL-11/IL-17 when compared to GCP group. The high positivity of  P. gingivalis  in the dental plaque was associated with significantly increased GCF levels of IL-17 in GCP and GAgP patients.  Conclusions . The increased IL-17 level in GCF of GAgP suggests a potential role in the aetiopathogenesis. Meanwhile, the decreased ratio of IL-11/IL-17 might reflect an imbalance between the proinflammatory and anti-inflammatory cytokines in different periodontal diseases.

IL-17 and IL-11 GCF Levels in Aggressive and Chronic Periodontitis Patients: Relation to PCR Bacterial Detection