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Objective . To assess the short-term efficacy and safety of two kinds of Traditional Chinese herbal patches, Fufang Nanxing Zhitong Gao (FNZG) and Shangshi Jietong Gao (SJG), for painful knee osteoarthritis (OA).  Methods . Patients were randomly enrolled in a double-blind, placebo-controlled study to receive FNZG ( n  = 60), SJG ( n  = 60), or placebo patch ( n  = 30) for 7 days. Outcome measures included visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Traditional Chinese Medicine Syndrome Questionnaire (TCMSQ) subscale.  Results . Although there was no significant difference among, three groups in short-term pain management, patients receiving FNZG got significant improvement in symptom of fear of coldness as compared with placebo patch ( P  = 0.029). The most common local adverse events of rash, itching, erythema, and slightly damaged skin were observed in 7% of participants.  Conclusions . FNZG may be a useful treatment for symptom of knee OA and merits long-term study in broader populations.

Traditional Chinese Herbal Patch for Short-Term Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial