English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This study was designed to evaluate the  in vitro  antifungal activities of four traditional Chinese medicine (TCM) extracts. The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays. They were tested against six oral  Candida  species,  Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis,  and  Candida guilliermondii , including clinical isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients. It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all six  Candida  spp, and to isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients. The MIC values ranged from 16 to 128  μ g/mL. More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed. We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis.

evidence-based complementary and alternative medicine

Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral<i>Candida</i>Species and the Synergy with Fluconazole against Azole-Resistant<i>Candida albicans</i>

Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six OralCandidaSpecies and the Synergy with Fluconazole against Azole-ResistantCandida albicans