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1 Neonatal Intensive Care Unit, Division of Woman and Child, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium 2 Division of Pediatric Clinical Pharmacology, Children’s National Medical Center, Washington, DC, USA 3 Departments of Pediatrics, Pharmacology, and Physiology, The School of Medicine and Health Sciences George Washington University, Washington, DC, USA 4 Intensive Care Ward, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands

Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development: A Clinician’s Request for a More Integrated Approach