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We discuss the functional roles of β2-adrenergic receptors in skeletal muscle hypertrophy and atrophy as well as the adaptive responses of β2-adrenergic receptor expression to anabolic and catabolic conditions. β2-Adrenergic receptor stimulation using anabolic drugs increases muscle mass by promoting muscle protein synthesis and/or attenuating protein degradation. These effects are prevented by the downregulation of the receptor. Endurance training improves oxidative performance partly by increasing β2-adrenergic receptor density in exercise-recruited slow-twitch muscles. However, excessive stimulation of β2-adrenergic receptors negates their beneficial effects. Although the preventive effects of β2-adrenergic receptor stimulation on atrophy induced by muscle disuse and catabolic hormones or drugs are observed, these catabolic conditions decrease β2-adrenergic receptor expression in slow-twitch muscles. These findings present evidence against the use of β2-adrenergic agonists in therapy for muscle wasting and weakness. Thus, β2-adrenergic receptors in the skeletal muscles play an important physiological role in the regulation of protein and energy balance

journal of biomedicine and biotechnology

Muscle Plasticity and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mrow><mml:mi mathvariant="bold">β</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant="bold">2</mml:mn></mml:mrow></mml:msub></mml:math>-Adrenergic Receptors: Adaptive Responses of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mrow><mml:mi mathvariant="bold">β</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant="bold">2</mml:mn></mml:mrow></mml:msub></mml:math>-Adrenergic Receptor …

Muscle Plasticity andβ2-Adrenergic Receptors: Adaptive Responses ofβ2-Adrenergic Receptor …