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Muscle lipid oxidation is stimulated by peroxisome proliferator-activated receptor (PPAR)  δ  or adiponectin receptor signalling. We studied human myocyte expression of the PPAR δ  and adiponectin receptor genes and their relationship to lipid parameters of the donors. The mRNA levels of the three adiponectin receptors, AdipoR1, AdipoR2, and T-cadherin, were highly interrelated ( r  ≥ 0.91). However, they were not associated with GPBAR1, an unrelated membrane receptor. In addition, the adiponectin receptors were positively associated with PPAR δ  expression ( r  ≥ 0.75). However, they were not associated with PPAR α . Using stepwise multiple linear regression analysis, PPAR δ  was a significant determinant of T-cadherin ( P  = .0002). However, pharmacological PPAR δ  activation did not increase T-cadherin expression. The myocyte expression levels of AdipoR1 and T-cadherin were inversely associated with the donors' fasting plasma triglycerides ( P  < .03). In conclusion, myocyte expression of PPAR δ  and the adiponectin receptors are highly coordinated, and this might be of relevance for human lipid metabolism in vivo.

The Myocyte Expression of Adiponectin Receptors and PPARδ Is Highly Coordinated and Reflects Lipid Metabolism of the Human Donors