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The  M. tuberculosis  phosphate-binding transporter lipoproteins PstS1 and PstS3 were good immunogens inducing CD8 +  T-cell activation and both Th1 and Th17 immunity in mice. However, this antigen-specific immunity, even when amplified by administration of the protein with the adjuvant LTK63 or by the DNA priming/protein boosting regimen, was not able to contain  M. tuberculosis  replication in the lungs of infected mice. The lack of protection might be ascribed with the scarce/absent capacity of PstS1/PstS3 antigens to modulate the IFN- γ  response elicited by  M. tuberculosis  infection during which, however, PstS1-specific IL-17 secreting cells were generated in both unvaccinated and BCG-vaccinated mice. In spite of a lack of protection by PstS1/PstS3 immunizations, our results do show that PstS1 is able to induce IL-17 response upon  M. tuberculosis  infection which is of interest in the study of anti- M. tuberculosis  immunity and as potential immunomodulator in combined vaccines.

clinical and developmental immunology/clinical and developmental immunology

The<i>M. tuberculosis</i>Phosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection against<i>M. tuberculosis</i>Infection

TheM. tuberculosisPhosphate-Binding Lipoproteins PstS1 and PstS3 Induce Th1 and Th17 Responses That Are Not Associated with Protection againstM. tuberculosisInfection