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We previously demonstrated that IgG responses to a panel of 126 prostate tissue-associated antigens are common in patients with prostate cancer.  In the current report we questioned whether changes in IgG responses to this panel might be used as a measure of immune response, and potentially antigen spread, following prostate cancer-directed immune-active therapies.  Sera were obtained from prostate cancer patients prior to and three months following treatment with androgen deprivation therapy (=34), a poxviral vaccine (=31), and a DNA vaccine (=21).  Changes in IgG responses to individual antigens were identified by phage immunoblot.  Patterns of IgG recognition following three months of treatment were evaluated using a machine-learned Bayesian Belief Network (ML-BBN).  We found that different antigens were recognized following androgen deprivation compared with vaccine therapies.  While the number of clinical responders was low in the vaccine-treated populations, we demonstrate that ML-BBN can be used to develop potentially predictive models

IgG Responses to Tissue-Associated Antigens as Biomarkers of Immunological Treatment Efficacy