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<p/> <p><it>Objectives</it>. To investigate whether lifestyle-only intervention in obese children who maintain or lose a modest amount of weight redistributes parameters of body composition and reverses metabolic abnormalities. <it>Study Design</it>. Clinical, anthropometric, and metabolic parameters were assessed in 111 overweight or obese children (CA of 11.3 ± 2.8 years; 63 females and 48 males), during 8 months of lifestyle intervention. Patients maintained or lost weight (1–5%) (group A; n: 72) or gained weight (group B). <it>Results</it>. Group A patients presented with a decrease in systolic blood pressure (SBP) and diastolic blood pressure (DBP) (<inline-formula><graphic file="1687-9856-2011-241703-i1.gif"/></inline-formula> and <inline-formula><graphic file="1687-9856-2011-241703-i2.gif"/></inline-formula>, resp.), BMI (<inline-formula><graphic file="1687-9856-2011-241703-i3.gif"/></inline-formula>), z-score BMI (<inline-formula><graphic file="1687-9856-2011-241703-i4.gif"/></inline-formula>), waist circumference (<inline-formula><graphic file="1687-9856-2011-241703-i5.gif"/></inline-formula>), fat mass (<inline-formula><graphic file="1687-9856-2011-241703-i6.gif"/></inline-formula>), LDL-C (<inline-formula><graphic file="1687-9856-2011-241703-i7.gif"/></inline-formula>), Tg/HDL-C ratio (<inline-formula><graphic file="1687-9856-2011-241703-i8.gif"/></inline-formula>), fasting and postprandial insulin (<inline-formula><graphic file="1687-9856-2011-241703-i9.gif"/></inline-formula>), and HOMA (<inline-formula><graphic file="1687-9856-2011-241703-i10.gif"/></inline-formula>), while HDL-C (<inline-formula><graphic file="1687-9856-2011-241703-i11.gif"/></inline-formula>) and QUICKI increased (<inline-formula><graphic file="1687-9856-2011-241703-i12.gif"/></inline-formula>). Conversely, group B patients had an increase in BMI (<inline-formula><graphic file="1687-9856-2011-241703-i13.gif"/></inline-formula>), waist circumference (<inline-formula><graphic file="1687-9856-2011-241703-i14.gif"/></inline-formula>), SBP (<inline-formula><graphic file="1687-9856-2011-241703-i15.gif"/></inline-formula>), and in QUICKI (<inline-formula><graphic file="1687-9856-2011-241703-i16.gif"/></inline-formula>), while fat mass (<inline-formula><graphic file="1687-9856-2011-241703-i17.gif"/></inline-formula>), fasting insulin (<inline-formula><graphic file="1687-9856-2011-241703-i18.gif"/></inline-formula>), and HOMA (<inline-formula><graphic file="1687-9856-2011-241703-i19.gif"/></inline-formula>) decreased. Lean mass, DBP, lipid concentrations, fasting and postprandial glucose, postprandial insulin, and ultrasensitive C-reactive protein (CRP) remained stable. <it>Conclusions</it>. Obese children who maintain or lose a modest amount of weight following lifestyle-only intervention tend to redistribute their body fat, decrease blood pressure and lipid levels, and to improve parameters of insulin sensitivity.</p

international journal of pediatric endocrinology/international journal of pediatric endocrinology

Limited Weight Loss or Simply No Weight Gain following Lifestyle-Only Intervention Tends to Redistribute Body Fat, to Decrease Lipid Concentrations, and to Improve Parameters of Insulin Sensitivity in Obese Children