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Autoantibodies targeting the  β   1 -adrenergic receptor (AAB- β   1 ) display agonist-like effects, which may have a pathogenic role in the progression of heart failure. Here, we used the electrophysiological recordings to explore the effects of AAB- β   1 -positive serum from Chinese patients with heart failure on the activity of the peak transient outward potassium current ( I   to ) and the end 50 ms steady-state potassium current ( I   ss ) in mouse cardiac myocytes. We found that the AAB- β   1 -positive serum had no effect on the activity of  I   to , but it produced a decrease in the currents of  I   ss . A low concentration of positive serum (1/100) had a small inhibitory effect on  I   ss . However, positive serum at 1 : 10, 1 : 20, and 1 : 50 significantly decreased  I   ss . The concentration-dependence analysis showed that the EC 50  of AAB- β   1 -positive serum was 1/60.24 and its nH was 2.86. It indicated that the AAB- β   1  could inhibit  I   ss  in mouse cardiomyocyte in a concentration-dependent manner.

clinical and developmental immunology/clinical and developmental immunology

Serum Positive for the Autoantibody against theβ1-Adrenoceptor from Chinese Patients with Congestive Heart Failure DecreasesIssin Mouse Cardiac Myocytes