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CD8+ T cells have been shown to capture plasma membrane fragments from target cells expressing their cognate antigen, a process termed &#8220;trogocytosis&#8221;. Here, we report that human CD4, the Human Immunodeficiency Virus (HIV) receptor, can be found among the proteins transferred by trogocytosis. CD4 is expressed in a correct orientation after its capture by CD8+ T cells as shown by its detection using conformational antibodies and its ability to allow HIV binding on recipient CD8+ T cells. Although we could not find direct evidence for infection of CD8+ T cells having captured CD4 by HIV, CD4 was virologically functional on these cells as it conferred on them the ability to undergo syncytia formation induced by HIV-infected MOLT-4 cells. Our results show that acquisition of CD4 by CD8+ T cells via trogocytosis could play a previously unappreciated role for CD8+ T cells in HIV spreading possibly without leading to their infection

journal of biomedicine and biotechnology

Could CD4 Capture by<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mtext>CD</mml:mtext><mml:msup><mml:mn mathvariant="bold">8</mml:mn><mml:mo mathvariant="bold">+</mml:mo></mml:msup></mml:mrow></mml:math>T Cells Play a Role in HIV Spreading?

Could CD4 Capture byCD8+T Cells Play a Role in HIV Spreading?