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NF- κ B comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF- κ B in inflammation and atherosclerosis and the regulation of the NF- κ B signaling pathway are summarized. The structure, function, and regulation of the NF- κ B inhibitors, I κ B α  and I κ B β , are reviewed. The regulation of NF- κ B activity by glucocorticoid receptor (GR) signaling and I κ B α  sumoylation is also discussed. This paper focuses on the recently reported regulatory function that adipocyte enhancer-binding protein 1 (AEBP1) exerts on NF- κ B transcriptional activity in macrophages, in which AEBP1 manifests itself as a potent modulator of NF- κ B via physical interaction with I κ B α  and a critical mediator of inflammation. Finally, we summarize the regulatory roles that recently identified I κ B α -interacting proteins play in NF- κ B signaling. Based on its proinflammatory roles in macrophages, AEBP1 is anticipated to serve as a therapeutic target towards the treatment of various inflammatory conditions and disorders.

Regulation of IB Function and NF-B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages