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Background/Aims. 20 Kilodalton-hGH (20&#x02009;K-hGH) is the second most abundant pituitary GH variant after 22&#x02009;K-hGH. In the steady state the proportion of 20&#x02009;:&#x02009;22&#x02009;K-hGH appears constant; does this proportion change with repetitive somatotroph stimulation? Methods. Forty adult males were randomised to receive a GHRH(1&#8211;29)NH2 bolus (0.5&#x02009;&#x03BC;g/kg (n=20) or 1.0&#x02009;&#x03BC;g/kg (n=20)), preceded or followed by a saline bolus, 1 week apart. Four to six weeks later, 10 subjects received 0.5&#x02009;&#x03BC;g/kg GHRH(1&#8211;29)NH2 at 0, 60, 120, and 180 minutes. Clearance rate of 22 and 20&#x02009;K-hGH was measured in 10 subjects. Results. Total amount/proportion of 22&#x02009;K-hGH/20&#x02009;K-hGH secreted was similar for both GHRH(1&#8211;29)NH2 doses. Repetitive stimulation reduced the amount of 22&#x02009;K-hGH released whereas the amount of 20&#x02009;K-hGH did not change significantly leading to an increase in the proportion of 20&#x02009;K-hGH (P=.05). Half-life of 20 and 22&#x02009;K-hGH were not significantly different (P=.55). Conclusions. Repetitive stimulation of the somatotroph may alter the proportion of GH variant released

international journal of pediatric endocrinology/international journal of pediatric endocrinology

Repetitive Stimulation of the Pituitary with Growth-Hormone-Releasing Hormone Alters the Proportion of 22 and 20 Kilodalton Human-Growth Hormone Released