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MAP kinases (MAPK) are involved in the regulation of cellularprocesses such as reproduction and growth. In parasites, the roleof MAPK  has been scarcely studied. Here, we describe theparticipation of an ERK-like protein in estrogen-dependentreproduction of the helminth parasite Taeniacrassiceps. Our results show that 17β-estradiolinduces a concentration-dependent increase in the bud number of invitro cultured cysticerci. If parasites are also incubated inpresence of an ERK-inhibitor, the stimulatory effect of estrogenis blocked. The expression of ERK-like mRNA and its correspondingprotein was detected in the parasite. The ERK-like protein wasover-expressed by all treatments. Nevertheless, a strong inductionof phosphorylation of this protein was observed only in responseto 17β-estradiol. Cross-contamination by host cells wasdiscarded by flow cytometry analysis. Parasite cells expressingthe ERK-like protein were exclusively located at the subtegumenttissue by confocal microscopy. Finally, the ERK-like protein wasseparated by bidimensional electrophoresis and then sequenced,showing the conserved TEY activation motif, typical of all knownERK 1/2 proteins. Our results show that an ERK-like protein isinvolved in the molecular signalling during the interactionbetween the host and T. crassiceps, and may beconsidered as target for anti-helminth drugs design

A New MAP Kinase Protein Involved in Estradiol-Stimulated Reproduction of the Helminth ParasiteTaenia crassiceps