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T cells develop into two major populations distinguished by their T cell receptor (TCR) chains. Cells with the  α   β  TCR generally express CD4 or CD8 lineage markers and mostly fall into helper or cytotoxic/effector subsets. Cells expressing the alternate  γ   δ  TCR in humans generally do not express lineage markers, do not require MHC for antigen presentation, and recognize nonpeptidic antigens. We are interested in the dominant V γ 2V δ 2+ T cell subset in human peripheral blood and the control of effector function in this population. We review the literature on  γ   δ  T cell generation and repertoire selection, along with recent work on CD56 expression and defining a cytotoxic/effector lineage within the phosphoantigen-reactive V γ 2V δ 2 cells. A unique mechanism for MHC-independent repertoire selection is linked to the control of effector function that is vital to the role for  γ   δ  T cells in tumor surveillance. Better understanding of these mechanisms will improve our ability to exploit this population for tumor immunotherapy.

clinical and developmental immunology/clinical and developmental immunology

Repertoire Development and the Control of Cytotoxic/Effector Function in Human<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>γ</mml:mi><mml:mi>δ</mml:mi></mml:mrow></mml:math>T Cells

Repertoire Development and the Control of Cytotoxic/Effector Function in HumanγδT Cells