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A/J mice were found to have amino acid differences in Naip5, one of the NOD-like receptors (NLRs) involved in the cytosolic recognition of pathogen-associated molecular patterns and one of the adaptor proteins for caspase-1 activation. This defect was associated with a susceptibility to  Legionella  infection, suggesting an important role for Naip5 in the immune response also to other intracellular pathogens, such as  Mycobacterium leprae . In this study, the immune responses of macrophages from A/J mice against  M. leprae  were compared to those of macrophages from C57BL/6 mice. Infection with  M. leprae  induced high levels of TNF- α  production and NF- κ B activation in A/J and C57BL/6 macrophages. Caspase-1 activation and IL-1 β  secretion were also induced in both macrophages. However, macrophages from A/J mice exhibited reduced caspase-1 activation and IL-1 β  secretion compared to C57BL/6 macrophages. These results suggest that NLR family proteins may have a role in the innate immune response to  M. leprae .

mediators of inflammation

Comparison of Two Mice Strains, A/J and C57BL/6, in Caspase-1 Activity and IL-1<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>β</mml:mi></mml:math>Secretion of Macrophage to<i>Mycobacterium leprae</i>Infection

Comparison of Two Mice Strains, A/J and C57BL/6, in Caspase-1 Activity and IL-1βSecretion of Macrophage toMycobacterium lepraeInfection