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DNA vaccination can induce specific CD8+ T cell immune response, but the response level is low in large mammals and human beings. Coadministration of an adjuvant can optimize protective immunity elicited by a DNA vaccine. In this study, we investigated the effect of a synthetic glucohexaose (&#x03B2;-glu6), an analogue of Lentinan basic unit, on specific CD8+ T cell response induced by a DNA vaccine encoding HBcAg (pB144) in mice. We found that &#x03B2;-glu6 promoted the recruitment and maturation of dendritic cells, enhanced the activation of CD8+ and CD4+ T cells and increased the number of specific CD8+/IFN-&#x03B3;+ T cells in lymphoid and nonlymphoid tissues in mice immunized by pB144. Immunization with pB144 and &#x03B2;-glu6 increased the anti-HBc IgG and IgG2a antibody titer. These results demonstrate that &#x03B2;-glu6 can enhance the virus-specific CTL and Th1 responses induced by DNA vaccine, suggesting &#x03B2;-glu6 as a candidate adjuvant in DNA vaccination

journal of biomedicine and biotechnology

<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>β</mml:mi></mml:math>-Glucan Oligosaccharide Enhances<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mtext>CD</mml:mtext><mml:msup><mml:mn mathvariant="bold">8</mml:mn><mml:mtext>+</mml:mtext></mml:msup></mml:mrow></mml:math>T Cells Immune Response Induced by a DNA Vaccine Encoding Hepatitis B Virus Core Antigen

β-Glucan Oligosaccharide EnhancesCD8+T Cells Immune Response Induced by a DNA Vaccine Encoding Hepatitis B Virus Core Antigen