Open AccessElectrochemical Reduction Behaviour of Zileuton at a Dropping Mercury Electrode by Polarography
Author(s) -
N. Y. Sreedhar,
M. Sankara Nayak,
K. S. S. Prasad,
P. Reddy Prasad,
C. Nageswar Reddy
Publication year - 2009
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2090-9071
pISSN - 2090-9063
DOI - 10.1155/2010/251415
Subject(s) - polarography , dropping mercury electrode , chemistry , electrochemistry , electrode , zileuton , analytical chemistry (journal) , mercury (programming language) , working electrode , inorganic chemistry , chromatography , organic chemistry , arachidonic acid , arachidonate 5 lipoxygenase , programming language , computer science , enzyme
Electrochemical behaviour of anticancer drug zileuton was investigated by direct current polarography (DCP) and differential pulse polarography using a dropping mercury electrode (DME) as working electrode and Ag/AgCl reference electrode in universal buffer of pH range from 2.0 to 12.0. The drug was extracted from the dosage forms in dimethyl formamide (DMF). Kinetic parameters such as diffusion co-efficient (D) and heterogeneous forward rate constants (k0f,h) are evaluated and reported. The differential pulse polarographic method has been developed for the determination of this drug in pharmaceutical formulations
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