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. The Chinese extract  Rhizoma coptidis  is well known for its anti-inflammatory, antioxidative, antiviral, and antimicrobial activity. The exact mechanisms of action are not fully understood.  Methods . We examined the effect of the extract and its main compound, berberine, on LPS-induced inflammatory activity in a murine macrophage cell line. RAW 264.7 cells were stimulated with LPS and incubated with either  Rhizoma coptidis  extract or berberine. Activation of AP-1 and NF κ B was analyzed in nuclear extracts, secretion of MCP-1/CCL2 was measured in supernatants.  Results . Incubation with  Rhizoma coptidis  and berberine strongly inhibited LPS-induced monocyte chemoattractant protein (MCP)-1 production in RAW cells. Activation of the transcription factors AP-1 and NF κ B was inhibited by  Rhizoma coptidis  in a dose- and time-dependent fashion.  Conclusions. Rhizoma coptidis  extract inhibits LPS-induced MCP-1/CCL2 production  in vitro  via an AP-1 and NF κ B-dependent pathway. Anti-inflammatory action of the extract is mediated mainly by its alkaloid compound berberine.

mediators of inflammation

<i>Rhizoma coptidis</i>Inhibits LPS-Induced MCP-1/CCL2 Production in Murine Macrophages via an AP-1 and NF<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>κ</mml:mi></mml:math>B-Dependent Pathway

Rhizoma coptidisInhibits LPS-Induced MCP-1/CCL2 Production in Murine Macrophages via an AP-1 and NFκB-Dependent Pathway