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The peroxisome proliferator-activated receptors (PPAR's) are members of the steroid/thyroid nuclear receptor, superfamily of transcription factors. There are currently three known PPAR subtypes,  α ,  β , and  γ . The PPARs are now recognized participants in a number of biological pathways some of which are implicated in the pathogenesis of age-related macular degeneration (AMD). These include immune modulation, lipid regulation, and oxidant/antioxidant pathways important to the onset and  progression of “dry” AMD, and vascular endothelial  growth factor (VEGF) mediated pathways that stimulate choroidal  neovascularization (CNV), characteristic of “wet” AMD.  PPAR- α  is found in retina and also on vascular cells  important to formation of CNV. At this time, however, relatively  little is known about potential contributions of PPAR- α  to the pathogenesis of dry and wet AMD. This review examines current literature for potential roles of PPAR- α  in the pathogenesis and potential treatment of AMD with emphasis on prevention and treatment of wet AMD.

ppar research

PPAR-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>α</mml:mi></mml:math>Ligands as Potential Therapeutic Agents for Wet Age-Related Macular Degeneration

PPAR-αLigands as Potential Therapeutic Agents for Wet Age-Related Macular Degeneration