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A novel tri- n -butyl(IV) derivative of 2-thiobarbituric acid (HTBA) of formula [( n -Bu) 3 Sn(TBA) H 2 O] (1) has been synthesized and characterized by elemental analysis and  119 Sn-NMR and FT-IR spectroscopic techniques. The crystal structure of  complex  1  has been determined by single crystal X-ray diffraction analysis  at 120(2) K. The geometry around Sn(IV) is trigonal bipyramidal. Three  n -butyl groups and one oxygen atom from a deprotonated 2-thiobarbituric ligand are bonded to the metal center. The geometry is completed with one oxygen from a water molecule. Compound  1  exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal  tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis. In addition, the inhibition  caused by  1 , in the rate of lipoxygenase ( LOX ) catalyzed oxidation  reaction of linoleic acid to hyperoxolinoleic acid, has been also kinetically and theoretically studied. The results are compared to  that of cisplatin.

bioinorganic chemistry and applications/bioinorganic chemistry and applications

Crystal Structure and Antitumor Activity of the Novel Zwitterionic Complex of tri-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="E1"><mml:mi>n</mml:mi></mml:math>-Butyltin(IV) with 2-Thiobarbituric Acid

Crystal Structure and Antitumor Activity of the Novel Zwitterionic Complex of tri-n-Butyltin(IV) with 2-Thiobarbituric Acid