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CeF3:Tb3+ nanoparticles were successfully prepared by a polyol process using diethylene glycol (DEG) as solvent. After being coated with dense silica, these CeF3:Tb3+ nanoparticles can be coated with mesoporous silica using nonionic triblock copolymer EO20PO70EO20 (P 123) as structure-directing agent. The composite can load ibuprofen and release the drug in the PBS. The composite was characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption/desorption isotherms, fluorescence spectra, and UV/Vis absorption spectra, respectively. The composite particles have considerable large pore volume and large surface area. In addition, the composite still emits strong green fluorescence (Tb3+) and can be used as fluorescent probes in drug delivery system.

Mesoporous Silica Coated CeF3:Tb3+ Particles for Drug Release