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CD25 + CD4 +  regulatory T cells suppress T cell activation and regulate multiple immune reactions in in vitro and in vivo studies. To define the regulatory function of human CD25 + CD4 +  T cells at various stages of maturity, we investigated in detail the functional differences of CD25 + CD4 +  T cells from thymocytes, cord blood (CB), and adult peripheral blood (APB). CB CD25 + CD4 +  T cells displayed low-FOXP3 protein expression level and had no suppressive activity. In contrast, CD25 + CD4 +  T cells from thymocytes or APB expressed high expression level of FOXP3 protein associated with significant suppressive activity. Although CB CD25 + CD4 +  T cells exhibited no suppressive activity, striking suppressive activity was observed following expansion in culture associated with increased FOXP3 expression and a shift from the CD45RA +  to the CD45RA −  phenotype. These functional differences in CD25 + CD4 +  T cells from Thy, CB, and APB hence suggest a pathway of maturation for Treg in the peripheral immune system.

clinical and developmental immunology/clinical and developmental immunology

Comparative Study of Regulatory T Cell Function of Human<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mtext>CD25</mml:mtext><mml:mtext>+</mml:mtext></mml:msup></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mtext>CD4</mml:mtext><mml:mtext>+</mml:mtext></mml:msup></mml:math>T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood

Comparative Study of Regulatory T Cell Function of HumanCD25+CD4+T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood