Open AccessCytomegalovirus Pathogenesis in Transplantation
Author(s) -
Jane E. Grundy
Publication year - 1993
Publication title -
canadian journal of infectious diseases and medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1918-1493
pISSN - 1712-9532
DOI - 10.1155/1993/319621
Subject(s) - cytomegalovirus , disease , cytomegalovirus infection , pathogenesis , affect (linguistics) , immunology , transplantation , virus , medicine , pathogenicity , host factors , virology , biology , viral disease , herpesviridae , human cytomegalovirus , pathology , psychology , communication , microbiology and biotechnology
Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality in the immunocompromised;however, even within this group of patients, infection with CMV is not synonymous withdisease. A number of factors affect the pathogenicity of the virus. An understanding of the mechanisms bywhich CMV causes disease at different sites in the body, and of how U1at might vary with different patientgroups, is essential to the design of stategies for the prevention and treatment of disease. This reviewdiscusses the factors which affect the occurrence and type of CMV disease in different patient populations,and considers some of the underlying mechanisms which might contribute to pathology
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