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The development of primary abdominal lymphoma is a recognizedcomplication of gluten-sensitive enteropathy (GSE). ln five patients with GSE pluslymphoma, the distribution and function of peripheral blood lymphocytes were determinedand compared with 13 patients with GSE without lymphoma and with 28normal control subjects. The percentage of T cells was lower in patients with GSE andGSE with lymphoma than in controls, whereas patients with GSE plus lymphomahad a significantly increased number of peripheral blood B lymphocytes when comparedwith GSE patients or controls. There was no difference in K cell activity orlymphocyte responses to mitogens and antigens between controls, GSE or GSE pluslymphoma patients. Prospective studies are needed in patients with GSE co investigatewhether this fall in peripheral blood T cells and rise in B lymphocytes is a marker ofconcurrent lymphoma

Celiac Sprue and Abdominal Lymphoma: Studies on the Cell-Mediated Immune Response of Peripheral Blood Lymphocytes